The Magister

fuckingrecipes:

verdantdeer:

yamino:

tavrospetrock:

Having problems finding a lipstick color for your cosplay? Look no further. I just found someone’s video tutorial on how to make lipsticks out of crayons. In the video she says that she found out that all of her favourite lipsticks had lead and that she found out that she could make lipstick out of lead free crayons. The entire time I was watching this video, I thought that it would work amazingly for someone looking for some cerulean blue lipstick for Vriska or Jade green lipstick for Kanaya or maybe some other cosplay character who has a weird lipstick color. In the video she also says that you could mix crayon colors to make weird colors. 

I don’t even wear lipstick ever, but learning you can make it out of crayons now got me all excited to try it. o-o

Never buying lipstick again ever. I have basically everything I need (except crayons). Probably going to sub out shea butter for cocoa butter, and castor oil for olive oil and see how that works. SO EXCITED. 

ANY LIPSTICK-WEARING MOTHERFUCKERS WILL FIND THIS USEFUL. 

OR PEOPLE WHO PAINT THEIR SKIN IN ANY MANNER. 

IDK I JUST FOUND THIS RECIPE FASCINATING AS HELL!

SKIP TO 1:46 IF YOU DON’T CARE ABOUT THE HISTORY AND JUST WANT SOME BALLIN’ LIPSTICK-LIKE SUBSTANCES OF VARYING COLORS. 

GO TO HER YOUTUBE COMMENTS TO FIND SUBSTITUTES IF YOU NEED THEM. 

FUCK YEAH!

(Source: youtube.com)

spoonfulofsterek:

CAN WE TALK ABOUT JOHNNY BRAVO FOR A SECOND?

• utilizes rule 63
• drives home the point that street harassment is not flattering
• johnny bravo appreciates being a woman and doesn’t question his masculinity

spadekeeperwitch:

Bayonetta 2

mythrilarrow:

My latest LARP character inspiration for Binx. Dat armor.

I think she’s supposed to be in Orlais

(Source: ixhaku)

condorheroofchaos:

undeath-is-fundeath:

thegameisalife:

Teclado de Portal visto aquí . Nos lo envía @DanielRoz0

I bet the escape button doesn’t work

you had to go there didn’t you

confidentinmyskinn:

rhosyncalypso:

weasleyappreciationblog:

nick-lang-is-twilight-sparkle:

the-feminist-librarian:

feministdykeslut:

slutshamersonfb:

TRIGGER WARNING

This is a Scottish anti-rape PSA that is a direct response to blaming a rape victim for dressing like a slut. What do you think? Is it effective?

ummmmm YES.

we need PSA’s like this in the U.S. asap. this video gets to the point of what rape culture is and is very serious about it.

WIN WIN WIN WIN

Wow, absolutely. This was amazing, and it was only thirty seconds.

this is fantastic

This!! Show this in the states! 

Fucking brilliant

all-blues:

僕らが進めば

science-junkie:

Gene survival and death on the human Y chromosome
By M. Wilson Sayres

In humans, genetic females have two X chromosomes and genetic males have one X chromosome and one Y chromosome:
You might have noticed from the cartoon above that the human Y is much smaller than the human X. But, it wasn’t always this way. Ancestrally, the human X and Y were the same size, and had the same genes. Over time, however, the Y has shrunk, but both the X and Y have also gained some genes. To better understand how the X and Y became so different, and how the evolution of the two sex chromosomes are correlated, we asked three main questions:

What has been lost from the Y?
To know which genes were lost, we first had to identify which genes were on the ancestral sex chromosome pair. By comparing the genes on the human X with the genes the X in other species, we identified a set of genes that were likely on the ancestral X chromosome: 600 in total. Then, by searching the Y chromosome for the relics of all of these genes, we identified three classes of sex-linked genes. We should think of each of the 600 ancestral genes as a pair (with one copy on the X, and one on the Y). All of these pairs have a working copy on the human X. Some pairs have a working (functional) copy on the Y, some have a broken copy on the Y (degraded), and some are missing their Y-copy.

Many genes have been lost from the ancestral Y, but a few persist. So, while some Y-linked genes have survived (I have another paper discussing this), and there have been some unique additions to the Y chromosome, we can see that the Y has lost functional capabilities for 96.83% of the genes that it once shared with the X. Wow!

Are there indicators of whether a Y-linked gene will be retained?
We can learn about the evolution of the sex chromosomes by studying differences between classes of sex-linked genes defined above. Specifically we asked, do features of X-linked genes suggest whether their Y-linked partner are retained or lost? In some cases, yes, they do.

First, we found that human X-linked genes with very few changes across mammals were more likely to have a working Y copy. So, if a gene is important enough to survive over long evolutionary time in roughly the same condition across very different species, then it might be very useful to the organism, so it would be important to have that gene in a working form in both males and females in the same species (human).

Second, we looked at expression. Genes can sometimes be “on” (which we would call expressed) or “off” (not expressed), but more often they can fall within a range. It’s like a light with a dimmer switch. The light can be turned on very brightly, but can also dimmed to a very low level without being “off”.  We found that X-linked genes that were highly expressed (bright) were more likely to have a working Y copy. This might mean that, for these genes, the level of “brightness” or expression is important, so that it is highly beneficial for these genes to be working very hard in both females and in males.

Does gene loss on the Y affect the evolution the X?
Okay, so some features of the X-linked partner might predict whether it’s Y-linked partner will survive, but is there any feedback from the Y back to the X chromosome? Yes!

Let’s think back to that first picture: females have two “big” X chromosomes, while males have one “big” X and one “little” Y. And, I’ve shown you that the Y chromosome has lost (either because of broken copies, or completely lost) almost 97% of the genes that it once shared with the X. This might lead you to believe that there are more genes expressed in females than in males. But, in many mammals, females silence most of the genes on one of their X chromosomes (X-inactivation), to equalize the dosage of genes expressed between males and females.

Although it has been hypothesized, we showed that the pattern of genes subject to silencing in females among the three classes above is consistent with a process whereby silencing evolves in response to gene loss on the Y chromosome. Moreover, this pattern suggests that some amount of time must pass to allow the signal (that the Y-linked partner is no longer working) to reach the X-chromosome before silencing can occur.

The paper is open access, so if you are curious, you can read it on Molecular Biology and Evolution.

Source: pandasthumb.org

chuck-charles:

_{[x] Feminist Makeup Tutorial (Parody)} 

THERES GIFS O F ME I’M YELLING ???????

(Source: jasongrace)